Smoking.
I just lost a friend. She had a bad cough with pain in her back. It was misdiagnosed until September. It turned out to be Stage 4 lung cancer. The pain was due to a large tumor. Imagine going from not knowing you even have cancer to being told you are in the final stages with mere months to live, all in the same moment. It was too large to operate and incurable. She did chemo / radiation but it didn't work. It wiped out any energy she had left. She went downhill fast. By Christmas she was bedridden. She moved in with her daughter. This past month she suffered a lot and wasted away. And now she's dead. Early 60's. She had a really, really hard life but finally got a glimmer of happiness as she recently got a grandson a few years ago who became the center of her world. Now she has been ripped away from him. She was already a seasoned smoker when I met her 20 years ago. She did quit for a long time. Didn't prevent this, though. As I type this, I am looking out the window, watching a man smoking. Damn.