Using your figures, the loan will be a Non-Agency Jumbo ($1.125m). Most lenders will want debt to income ratios to be below 43%, however some will OK 45% DTI, and even fewer up to 49.9. Please be aware that programs that allow higher DTI's often will have higher rates compared to those products with tighter ratios. Also, $500 per month auto debt is important to consider. If it's a lease, no matter if you pay it off, you've got to count that debt. If it's a loan, consider paying it off if DTI is above 43% and your mortgage rate suffers. Also, ARM loans may have a lower rate, but they are qualifying at index, plus margin - often in the low 7% range - so for this example, assume a 30 fixed.
Assuming 5.75% 30 fixed the PITIHOA will be around $8,400, plus your car means a grand total of $8,900. Mello Roos is the wild card here and omitted for simplicities sake.
43% DTI income is 20,700 per month
45% DTI income is $19,700 per month
49.9% DTI income is $17,835 per month.
These are gross income levels, not net, nor do they take in to account any rental property losses being shown if you have an investment home, or if you are converting a departure residence into a rental. Please use the above data as a theoretical example of qualifying income for your scenario, not as hard facts. An underwriter, not a loan officer, will need to review an application in its entirety to know what is possible and what might not work. It's a general, 10,000 ft overview of possible figures and not much else. PM me if you want to discuss specifics.